| CAS
NO. |
50370-12-2
(Base)
66592-87-8 (Monohydrate) |
|
| EINECS NO. |
256-555-6 |
| FORMULA |
C16H17N3O5S·H2O |
| MOL
WT. |
381.40 |
|
H.S.
CODE
|
2941.90 |
|
TOXICITY
|
|
| SYNONYMS |
Duricef; Ultracef; |
|
[6R-[6a,7b(R')]]-
7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-
thia-1- azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, monohydrate;
|
|
CLASSIFICATION
|
ANTIBOITICS
/ CEPHALOSPORINS
/
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
White to off-white crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Slightly
soluble |
| pH |
4.0
- 6.0 (50mg/ml solution) |
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Cephalosporin:
any of a group of broad-spectrum derived from species of fungi of the genus
Cephalosporium and are related to the penicillins in both structure and mode of
action but relatively penicillinase-resistant antibiotics. These antibiotics
have low toxicity for the host, considering their broad antibacterial spectrum.
They have the active nucleus of beta-lactam ring which results in a variety of
antibacterial and pharmacologic characteristics when modified mainly by
substitution at 3 and 7 positions. Their antibacterial activities result from
the inhibition of mucopeptide synthesis in the cell wall. They are widely used
to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal
infections. The cephalosporin class of antibiotics is usually divided into
generations by their antimicrobial properties. Three generations of
cephalosporins are recognized and the fourth has been grouped. Each newer
generation of cephalosporins has broader range of activity against gram-negative
organisms but a narrower range of activity against gram-positive organisms than
the preceding generation. The newer agents have much longer half-lives resulting
in the decrease of dosing frequency. Accordingly, the third-generation
cephalosporins can penetrate into tissues well, and thus antibiotic levels are
good in various body fluids.
Cefadroxil is a semisynthetic 1st generation cephalosporin antibiotic Inhibiting cell
wall biosynthesis. It is used especially in the treatment of respiratory and
urinary tract infections and is intended for oral administration. It is a white to off-white
crystalline powder; slightly soluble in water; insoluble in alcohol, chloroform,
and ether; stable in acid. The chemical designation is [6R-[6a,7b(R')]]- 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-
thia-1-azabicyclo [4.2.0] oct- 2-ene-2-carboxylic acid, monohydrate.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
White to off-white
crystalline powder |
|
IDENTIFICATION
|
Complies
(Test A,B)
|
|
ASSAY |
950
- 1050µg/mg
(Cefadroxil) |
|
CLARITY
OF SOLUTION
|
Complies
|
|
WATER |
4.2
- 6.0% |
|
pH
|
4.0
- 6.0 (50mg/ml solution) |
|
HEAVY
METALS
|
20ppm
max
|
|
IMPURITY
|
7 Amino Deacetoxycephalosporanic acid:
1.0% max
D-a-4-hydroxyphenyl
glycine: 1.0% max
Other total Impurity: 1.0% max |
| TRANSPORTATION |
| PACKING |
5kgs
- 20kgs |
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
Hazard
Symbols: XN, Risk Phrases: 42/43, Safety Phrases: 22-36/37
Price:
 |
